Eosinophilic enteropathy (EE) is a complicated digestive
system disorder where eosinophils, a type of white blood cell,
have an above normal amounts in one or more places of the
digestive system or blood.
Eosinophils release toxins that attack foreign allergens such
as allergy-triggering foods or airborne allergens. When the
body produces too many eosinophils they attack the body
causing chronic inflammation, polyps, ulcers, and tissue
damage.
This condition can be divided into two types primary and
secondary. The primary type can be divided into allergic and
non-allergic forms. The allergic type occurs with food
allergies and the non-allergic type occurs when no obvious
cause can be found to explain the high numbers of
eosinophils in the digestive system. Because of this the
non-allergic is thought to be evidence that the body is
attacking itself and considered to be and autoimmune
disorder.
Common symptoms may include: Pain, swelling, skin rash,
hives, reflux, choking, difficulty swallowing, nausea, vomiting,
loss of appetite, stools containing blood and/or mucus,
abdominal cramping, diarrhea, fever, esophageal rings,
bowel obstruction, bowel or stomach wall thickening, protein
loss, anemia, malabsorbation, developmental delay,
bleeding, and several other symptoms that occur in individual
cases.
Since there is no cure for eosinophilic enteropathy
management of the condition is very important in order to
prevent damage to the digestive system caused by high
numbers of eosinophils.
Normal Eosinophil Cells
Endoscopic image of polyps on
the esophagus.